Interactions of tizanidine with CYP1A2 enzyme inhibitors Studies in vitro and in humans
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چکیده
Academic Dissertation To be presented, with the permission of the Medical Faculty of the University of Helsinki, for public examination in the small lecture hall
منابع مشابه
Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions.
Rofecoxib was recently found to greatly increase plasma concentrations of the CYP1A2 substrate drug tizanidine in humans, but there are no published in vitro studies on the CYP1A2-inhibiting effects of rofecoxib. Our objective was to investigate whether rofecoxib is a direct-acting or metabolism-dependent inhibitor of CYP1A2 in vitro. The effect of rofecoxib on the O-deethylation of phenacetin ...
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تاریخ انتشار 2005